MCHC (mean corpuscular hemoglobin concentration)
Average concentration of hemoglobin in red blood cells
Also known as
Definition
MCHC (mean corpuscular hemoglobin concentration) shows how concentrated the hemoglobin in red blood cells is on average, that is, the amount of hemoglobin relative to the size of the cell. Together with MCV, MCH and RDW it belongs to the red blood cell indices, which are measured with the blood count. Together they help distinguish different types of anemia.
| Parameter | Value |
|---|---|
| Unit | g/dL (grams of hemoglobin per deciliter) |
| Reference Range | Typical for adults: 32–36 g/dL, equal to 320–360 g/L (normal range according to MedlinePlus). Labs differ slightly; the reference range on your own report is what counts. Discuss any deviation with your doctor. |
Agree on your personal target range with your doctor.
Conversion: 1 g/dL equals 10 g/L. Converted to amount of substance (our own calculation, based on the hemoglobin subunit), 1 g/dL equals about 0.62 mmol/L; 32–36 g/dL is therefore about 19.9–22.3 mmol/L.
↓ What a low value means
A low MCHC means that the hemoglobin in red blood cells is less concentrated on average. This can be linked to iron deficiency anemia or to thalassemia, a group of inherited blood disorders in which the body makes fewer healthy red blood cells and less hemoglobin. The value is interpreted together with MCV, MCH, hemoglobin and other blood results. Discuss the result with your doctor.
↑ What a high value means
A high MCHC means that the hemoglobin in red blood cells is more concentrated on average. This can be linked to hemolytic anemia, in which red blood cells are destroyed faster than the body can replace them. Hereditary spherocytosis is another possibility, a rare inherited disorder that can come with anemia and gallstones. Discuss the result with your doctor.
When to test
MCHC is measured with the blood count, for example during routine checkups or with signs of anemia such as tiredness, weakness, shortness of breath, headache, dizziness, an irregular heartbeat, pale skin or cold hands and feet. No special preparation is needed.
Frequently asked questions
How is MCHC different from MCH? +
MCH gives the average amount of hemoglobin per red blood cell. MCHC relates this amount to the size of the cell and so describes how concentrated the hemoglobin in the cell is. Together with MCV and RDW, both belong to the red blood cell indices.
Is MCHC enough on its own for a diagnosis? +
No. MCHC is always viewed together with the other red blood cell indices, hemoglobin and other blood results. Your doctor also takes your symptoms and medical history into account.
Why is MCHC sometimes given in g/dL, sometimes in g/L or mmol/L? +
Labs use different units. 32–36 g/dL equals 320–360 g/L; based on the hemoglobin subunit, that is about 19.9–22.3 mmol/L (our own calculation). Always compare values over time in the same unit.
Do I need to fast for an MCHC test? +
No, no special preparation is needed. The blood draw from a vein in your arm usually takes less than five minutes.
MCHC (mean corpuscular hemoglobin concentration)
Sources
Last updated: October 05, 2026
This information is for orientation only and does not replace medical advice. Reference ranges can vary by laboratory, method and country.