Lipase
Digestive enzyme for fats and a key lab value for the pancreas
Also known as
Definition
Lipase is a digestive enzyme that helps the body digest fats. Most of it is made by the pancreas; smaller amounts come from the salivary glands and the stomach. When the pancreas is damaged, larger amounts of lipase enter the blood. The test is therefore mainly used to detect acute inflammation of the pancreas (pancreatitis) and to follow the course of pancreatic diseases.
| Parameter | Value |
|---|---|
| Unit | U/l (µkat/l) |
| Reference Range | A small amount of lipase in the blood is normal. There is no universal numeric range because labs use different measurement methods and their own reference ranges; the reference range on your own report is what counts. Discuss any deviation with your doctor. |
Agree on your personal target range with your doctor.
Conversion: 1 U/l = 0.0167 µkat/l; 1 µkat/l = 60 U/l.
↓ What a low value means
Low lipase levels can be linked to permanent damage to the pancreatic cells that make lipase, for example in chronic conditions such as cystic fibrosis or chronic pancreatitis. A low value is always assessed together with symptoms and other findings. Discuss the result with your doctor.
↑ What a high value means
Very high lipase levels are usually linked to acute pancreatitis. Raised levels can also be linked to other pancreatic diseases such as a blocked pancreatic duct or pancreatic cancer, chronic kidney disease, a stomach or duodenal ulcer, gallbladder disease, intestinal problems such as a blocked bowel, diabetes, salivary gland disorders such as infection or cancer, or alcohol use disorder. An unusual value does not always mean a condition that needs treatment; many medicines can also affect it. Discuss the result with your doctor.
When to test
Lipase is measured with symptoms that may point to the pancreas, such as belly pain that may spread to the lower back, nausea, vomiting, fever, a fast heartbeat or jaundice, and to monitor known conditions. You may need to fast for 8–12 hours; your lab or practice will tell you what applies. Mention your medicines, but do not stop any on your own.
Frequently asked questions
What is the difference between lipase and amylase? +
Both are digestive enzymes that can rise in the blood when the pancreas is damaged. Lipase helps digest fats, amylase helps digest carbohydrates. Lipase is made mostly in the pancreas, while a large share of amylase also comes from the salivary glands.
Do I need to fast for a lipase test? +
Often yes: a fasting period of 8–12 hours may be required before the blood draw. Ask your lab or practice what applies to your appointment.
Which medicines can affect lipase levels? +
Examples include codeine, diuretics (water pills), certain cholesterol medicines and birth control pills. Mention all medicines and supplements, but do not stop any without talking to your doctor.
Does a high lipase level always mean pancreatitis? +
No. Besides pancreatic disease, conditions of the kidneys, gallbladder or bowel, for example, can also raise the value. Your doctor interprets it together with symptoms and further tests.
Lipase
Sources
Last updated: October 05, 2026
This information is for orientation only and does not replace medical advice. Reference ranges can vary by laboratory, method and country.